Drug shortages continue to put patients at risk.
As highlighted by The National Desk’s Spotlight on America, children with cancer and their families continue to face uncertainty when critical medicines like ifosfamide are in short supply.
For Abby Bray, this was personal. Patient One was Abby. Her experience navigating drug shortages during cancer treatment became the catalyst for Laura Bray’s advocacy and the founding of Angels for Change.
We remain committed to advancing solutions that strengthen the pharmaceutical supply chain and ensure every patient has access to the medicines they need.
Women across the country are struggling to access estrogen patches, with some traveling long distances, rationing medication, or searching for alternatives to maintain access to their treatment.
The New York Post recently examined the shortage and the challenges patients are facing. Laura Bray, Founder of Angels for Change, spoke with the publication about why the shortage was predictable following the FDA’s removal of the black box warning for estrogen-based hormone replacement therapy.
Announcing: A new milestone to strengthen U.S. readiness for critical medicines.
Today, Angels for Change and Medivant Healthcare announced the completion of a key Project PROTECT milestone, establishing ready-to-activate U.S. manufacturing capacity for 10% Calcium Chloride Injection, an essential medicine used in emergency and critical care.
Through the partnership, Medivant has completed development of Calcium Chloride Injection and advanced the medicine into Project PROTECT’s readiness phase, creating domestic manufacturing capacity that can be activated when supply disruptions threaten patient access.
“Project PROTECT is about staying ahead of shortages before they reach patients,” said Laura Bray, Chief Change Maker at Angels for Change. “By partnering with Medivant Healthcare to prepare domestic capacity for Calcium Chloride Injection, we are demonstrating what proactive shortage preparedness can look like and building the ability to respond before a supply disruption becomes a patient crisis.”
Since launching in 2022, Project PROTECT has strengthened U.S. readiness for 14 essential medicines, seven of which have subsequently experienced shortages, with more than 850,000 patient treatments accessed during shortages.
For the first time since 2019, Abby Bray is sharing her cancer journey in her own words.
For years, Abby kept her story private. Now, five years cancer-free, she is choosing to share her experience and use her voice to advocate for other patients facing drug shortages.
Abby was Patient One for Angels for Change.
Today, she is helping carry that mission forward as a member of the Angels for Change Patient Advocacy Board, which brings patients, caregivers, and lived experiences directly into our advocacy work.
Angels for Change (A4C) successfully concluded its sold out SummitONE 2026, its annual healthcare summit focused on strengthening pharmaceutical supply chain resilience, at Pfizer's headquarters in New York City. The two-day event brought together executives and experts from across the pharmaceutical ecosystem; including manufacturers, distributors, healthcare systems, regulators, policymakers, and patient advocates. SummitONE advances collaboration and actionable solutions to strengthen access to medicines and end drug shortages.
Drug shortages are making national headlines again as families search for critical medicines like leucovorin. In a recent CNN article, Angels for Change founder Laura Bray highlights how the crisis was predictable—and preventable. Through Project GOLD, Angels for Change works across the supply chain to locate scarce medications and help patients access the treatments they depend on, because no family should have to face a shortage alone.
At Angels for Change, we are proud to participate in the important work of the End Drug Shortages Alliance — serving as both an EDSA member organization and advising partner in the Drug Resiliency & Transparency Pilot.
The initial phase of the pilot demonstrated a powerful truth: when leaders come together early through trusted, neutral governance, transparency delivers real planning value.
Angels for Change today announced that the Mark Cuban Cost Plus Drug Company has completed the Preparation and Protective phases of Project PROTECT for Carboplatin Injection and Methotrexate Injection—two essential oncology medicines currently in nationwide shortage. This milestone strengthens onshore readiness and improves supply availability for patients across the United States.
Drug shortages are not just a supply chain problem—they are personal. In this Capitol Hill briefing hosted by U.S. Pharmacopeia (USP), patients share firsthand how medication shortages have disrupted care, created fear and uncertainty, and put lives at risk. Their stories underscore the urgent need for stronger policies, better transparency, and a more resilient drug supply system—because patients are counting on us.
New from Angels for Change: the launch of our Policy Lab.
The A4C Policy Lab brings together patients, clinicians, policymakers, and industry leaders to turn frontline experience into actionable policy solutions that address drug shortages at their root.
Last week on January 29th, 2026, Angels for Change convened a sold-out National Policy Lab on Capitol Hill in the historic Kennedy Caucus Room to tackle one of the most urgent issues in healthcare: the U.S. drug shortage crisis.
Angels for Change is translating patient harm into real-world policy solutions. This Policy Lab wasn’t a conference — it was a working session focused on collaboration, candor, and outcomes, with patients at the center of every solution.
Angels for Change — 2025 Year in Review
From supporting patients through dozens of different shortage crisis to launching a first-of-its-kind oncology resiliency program to shaping national policy conversations, 2025 was a year of bold action and patient-driven progress.
Together with partners across healthcare, government, and industry, we:
Protected patients during critical drug shortages
Launched Project GOLD to proactively safeguard cancer care
Protected 4 addition essential medicines for the American people with Project PROTECT
Elevated patient voices in policy and supply chain reform
Built momentum toward a more resilient medicine supply system
See how collaboration, transparency, and patient leadership are driving lasting change.
Nearly half of U.S. drug shortages, 47%, are tied to sudden spikes in demand, according to new data from the USP Medicine Supply Map. Angels for Change Project GOLD is highlighted in the article as a solution-oriented initiative that uses demand signals and buffer supply to help protect patients from shortages.
Laura Bray discusses the personal inspiration behind her nonprofit, Angels for Change in a December 2025 interview with Voyage Tampa. Motivated by her daughter's struggle with chemotherapy drug shortages, Bray transitioned from a business professor to lead an organization dedicated to solving pharmaceutical supply chain issues.
SHARE YOUR “WHY”
Every conversation, partnership, and shared story brings us closer to a future without drug shortages. At Angels for Change, we’re proud to march forth for patients everywhere.
